A-349 821




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| A-349,821 | Nootropic | Maryland_Route_821 | Anglo-Saxons | Histamine_H3_receptor | List_of_kings_of_Persia | H3_receptor_antagonist | List_of_Royal_Air_Force_aircraft_squadrons | Histamine_antagonist | National_Register_of_Historic_Places_listings_in_Utah | List_of_countries_by_past_and_future_GDP_(nominal)_per_capita | List_of_countries_by_past_and_future_GDP_(nominal) | List_of_countries_by_past_and_future_GDP_(PPP) | Muslim_ibn_al-Hajjaj | List_of_Japanese_prefectures_by_population | List_of_countries_by_past_and_future_GDP_(PPP)_per_capita | List_of_Russian_federal_subjects_by_GRP | 2012_Australian_football_code_crowds | Uyghur_Khaganate | List_of_municipalities_in_Pennsylvania | Frank_Worrell | List_of_compositions_by_Carl_Philipp_Emanuel_Bach | National_Register_of_Historic_Places_listings_in_Idaho | World_distribution_of_wealth | Table_of_prime_factors | List_of_counties_in_Kentucky | Douglas_County,_Oregon | California_gubernatorial_election,_1978 | List_of_Pennsylvania_locations_by_per_capita_income | California_State_Treasurer_election,_2002 | Results_of_the_New_South_Wales_state_election,_1978_(Legislative_Assembly_A-K) | Ontario_general_election,_1999 | Demographics_of_Norway | List_of_prime_numbers | List_of_the_largest_companies_of_Norway | List_of_countries_by_future_GDP_(PPP)_per_capita_estimates | Ontario_general_election,_1995 | U.S._Automobile_Production_Figures | Pennsylvania_statistical_areas | List_of_countries_by_future_population_(United_Nations,_Constant_variant) | Area_code_208 | Area_codes_905,_289_and_365 | California_locations_by_income | List_of_populated_places_in_Serbia | List_of_United_States_counties_and_county_equivalents | Kurunegala_Electoral_District | List_of_solar_eclipses_in_the_9th_century | Case_citation | List_of_highest-income_places_in_the_United_States |



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A-349,821


A-349,821
Systematic (IUPAC) name
(4'-[3-(2R,5R-dimethylpyrrolidin-1-yl)propoxy]biphenyl-4-yl)morpholin-4-ylmethanone
Clinical data
Legal status  ?
Identifiers
ATC code  ?
PubChem CID 9954017
IUPHAR ligand 1217
ChemSpider 8129627 YesY
ChEMBL CHEMBL179702 YesY
Chemical data
Formula C26H34N2O3 
Mol. mass 422.558
 YesY (what is this?)  (verify)

A-349,821 is a potent and selective histamine H3 receptor antagonist[1] (or possibly an inverse agonist).[2] It has nootropic effects in animal studies,[3] although there do not appear to be any plans for clinical development at present and it is currently only used in laboratory research.


A-349 821 See also


H3 receptor antagonist


A-349 821 References


  1. ^ Faghih, R; Dwight, W; Pan, JB; Fox, GB; Krueger, KM; Esbenshade, TA; McVey, JM; Marsh, K; Bennani, YL; Hancock, AA (2003). "Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists". Bioorganic & Medicinal Chemistry Letters 13 (7): 1325–8. doi:10.1016/S0960-894X(03)00118-5. PMID 12657274. 
  2. ^ Witte, DG; Yao, BB; Miller, TR; Carr, TL; Cassar, S; Sharma, R; Faghih, R; Surber, BW; Esbenshade, TA; Hancock, AA; Krueger, KM (2006). "Detection of multiple H3 receptor affinity states utilizing 3HA-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand". British Journal of Pharmacology 148 (5): 657–70. doi:10.1038/sj.bjp.0706752. PMC 1751875. PMID 16715122. 
  3. ^ Esbenshade, T. A.; Fox, G. B.; Krueger, K. M.; Baranowski, J. L.; Miller, T. R.; Kang, C. H.; Denny, L. I.; Witte, D. G.; Yao, B. B.; Pan, J. B.; Faghih, R.; Bennani, Y. L.; Williams, M.; Hancock, A. A. (2004). "Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist". Biochemical Pharmacology 68 (5): 933–945. doi:10.1016/j.bcp.2004.05.048. PMID 15294456. 


| A-349,821 | Nootropic | Maryland_Route_821 | Anglo-Saxons | Histamine_H3_receptor | List_of_kings_of_Persia | H3_receptor_antagonist | List_of_Royal_Air_Force_aircraft_squadrons | Histamine_antagonist | National_Register_of_Historic_Places_listings_in_Utah | List_of_countries_by_past_and_future_GDP_(nominal)_per_capita | List_of_countries_by_past_and_future_GDP_(nominal) | List_of_countries_by_past_and_future_GDP_(PPP) | Muslim_ibn_al-Hajjaj | List_of_Japanese_prefectures_by_population | List_of_countries_by_past_and_future_GDP_(PPP)_per_capita | List_of_Russian_federal_subjects_by_GRP | 2012_Australian_football_code_crowds | Uyghur_Khaganate | List_of_municipalities_in_Pennsylvania | Frank_Worrell | List_of_compositions_by_Carl_Philipp_Emanuel_Bach | National_Register_of_Historic_Places_listings_in_Idaho | World_distribution_of_wealth | Table_of_prime_factors | List_of_counties_in_Kentucky | Douglas_County,_Oregon | California_gubernatorial_election,_1978 | List_of_Pennsylvania_locations_by_per_capita_income | California_State_Treasurer_election,_2002 | Results_of_the_New_South_Wales_state_election,_1978_(Legislative_Assembly_A-K) | Ontario_general_election,_1999 | Demographics_of_Norway | List_of_prime_numbers | List_of_the_largest_companies_of_Norway | List_of_countries_by_future_GDP_(PPP)_per_capita_estimates | Ontario_general_election,_1995 | U.S._Automobile_Production_Figures | Pennsylvania_statistical_areas | List_of_countries_by_future_population_(United_Nations,_Constant_variant) | Area_code_208 | Area_codes_905,_289_and_365 | California_locations_by_income | List_of_populated_places_in_Serbia | List_of_United_States_counties_and_county_equivalents | Kurunegala_Electoral_District | List_of_solar_eclipses_in_the_9th_century | Case_citation | List_of_highest-income_places_in_the_United_States

Copyright:
Dieser Artikel basiert auf dem Artikel http://en.wikipedia.org/wiki/A-349_821 aus der freien Enzyklopaedie http://en.wikipedia.org bzw. http://www.wikipedia.org und steht unter der Doppellizenz GNU-Lizenz fuer freie Dokumentation und Creative Commons CC-BY-SA 3.0 Unported. In der Wikipedia ist eine Liste der Autoren unter http://en.wikipedia.org/w/index.php?title=A-349_821&action=history verfuegbar. Alle Angaben ohne Gewähr.

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